Consider The Evidence: Med/Peds Journal Roundup

February 9, 2006

Lowfat = Low Yield for preventing CVD? WHI data

Filed under: cardiovascular, diet, JAMA, WHI — medblog @ 6:01 pm

JAMA 2/8 –  Not exactly a home run for the healthy low-fat diet. It is often taken for granted that lowering dietary is key to preventing CVD, and some suggest it may even prevent cancer. However, prospective data on the matter is scarce. This weeks JAMA presents the results of a large RCT on Low-fat diets as part of the Women’s Health Initiative – and the results are not exaclty helping me fight my McDonalds addiction.

Ok so maybe I’m not a postmenopausal woman so I cant generalize too much. The article and accompanying editorial both argue that the trial was intended to study the effects on breast and colorectal cancer (negatory on those too) rather than CVD risk. The reduction in LDL levels (2.7mg/dl) achieved with the diet was too small to confer a detectable risk difference as the study was powered. Overall there was an 8% drop in fat intake at year 6. So maybe the diets need to be even more aggressive? In the mean time, I’m keeping my statins at the ready.

Howard BV, Van Horn L, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative randomized controlled Dietary Modification Trial. JAMA. 2006;295:655-666 



1 Comment »

  1. I like Chipotle.
    That’s a better addiction than McDonald’s !
    Guess who’s behind the Chipotle chain?

    If you guess McDonald’s, you are right!

    and I never go to McDonald anymore.

    but sad to say, I’m still fat
    (and I need help, it’s impacting my health)
    oh well.

    Comment by chowrescue — February 13, 2006 @ 12:45 pm

RSS feed for comments on this post. TrackBack URI

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

Create a free website or blog at

%d bloggers like this: