Consider The Evidence: Med/Peds Journal Roundup

April 27, 2006

More things vitamins dont work for

Filed under: NEJM, ob/gyn — medblog @ 1:37 pm

NEJM 4/27 – Although the precise mechanism for the start of pre-eclampsia is unclear, it has been proposed that oxidative stress is involved in creating the cellular and tissue dysfunction that underlie the syndrome. So naturally, a pilot study of antioxidants to reduce the risk of pre-eclampsia was done by Campbell, et al in 1999. That study showed promising results for the therapy, but futher research contradicted their findings.

Rumbold et al, present a multicenter RCT of nearly 2000 women on the effects of vitamin C and E supplementation in the latest New England. And, just as in most other studies of antioxidants, the supplementation showed no benefits. There was no significant difference in the risk of pre-eclampsia nor in the serious outcomes for the neonate. 

What will the next proposted target for the antioxidant strategy be? We shall see..


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