Consider The Evidence: Med/Peds Journal Roundup

July 13, 2006

Dont Re-Invent the Wheel with CRP

Filed under: archives of internal medicine, CHD, CRP — medblog @ 8:08 pm

ArchivesIM 7/10 – Ever since it was shown that CRP levels are strong predictors of CHD, the controversy has been whether it is really any better than the risk predictors we already have. Several articles have concluded that CRP in some way is a “better” method of stratifying CHD risk.

A paper by Fulstrom et al. addressing this issue presents data from the Atherosclerosis Risk in Communities (ARIC) Study. This was a prospective case cohort study. They looked at the reciever-operator curve using traditional risk factors, and then calculated the improvement of this curve once novel risk markers such as CRP, IL-6, pLA2, etc were added. They found that these fancy-schmancy molecules did not add significantly to the accuracy of the old prediction model.

So maybe CRP levels are a solution without a cause… but there is still a camp that believes that using that measure will include a group of higher-risk individuals that is not identified by the traditional risk factors…

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