Consider The Evidence: Med/Peds Journal Roundup

September 28, 2006

zzzzzz….all about sleep

Filed under: archives of internal medicine, Uncategorized — medblog @ 8:43 pm

So I’m an issue behind, but I had to blog on the sleep-themed Sept 18th issue of Archives of Int Med. (one of my favorite subjects). Just how important is it?

Steptoe et al. found that young adult subjects that slept less than 6 hours per night were almost twice as likely to report their health as being poor – even after adjustment for socioeconomic factors, physical activity, BMI and Beck Depression Inventory scores. However, I cant help be a little cautioned by the fact that both sleep time and health status were based on self-report.

From the basic science side, Irwin et al. found that monocyte production of the proinflammatory cytokines IL-6 and TNF-alpha was significantly higher on the morning after sleep deprivation. (sounds like a bad thing)

Arzt et al warn of a condition that may obscure the diagnosis of obstructive sleep apnea. Their research found that comorbid heart failure resulted in less daytime sleepiness in sufferers of OSA. Unfortumately, the detrimental effects of poor sleep remained present. Because excessive daytime sleepyness is often the presenting symptom leading to the diagnosis of OSA, the researchers caution that physicians may miss the presence of OSA in HF patients.

And in the midst of the obesity epidemic, Kothatsu et al. show that a significant inverse relationship between sleep duration and BMI also exists in a rural population. Other researchers have already shown the same to be true in the urban and suburban populations. But watch out for that giant 70% confidence interval.


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