Consider The Evidence: Med/Peds Journal Roundup

July 10, 2006

Decaf Drinkers Deftly Dodge Diabetes

Filed under: archives of internal medicine, caffeine, Coffee, diabetes, diet — medblog @ 11:02 am

ArchivesIM 5/26 – While there has been some recent controversy over the risks and benefits of coffee consumption for diseases such as diabetes and MI, the exact cause for these effects is unknown.

In the current Archives, Pereira et al. present further investigation of this phenomenon using data from an 11-year, 28,000 patient observational trial of post-menopausal women. They found a significant inverse relationship between coffee consumption and incidence of diabetes. In the most comprehensively adjusted model, the results were only significant for decaf drinkers. Unfortunately for the majority, the difference in this model was only significant for drinkers of 4-5, and 6+ cups a day.

Now if they can only explain the purpose of drinking decaf coffee at all, let alone more than six cups of it per day??

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March 11, 2006

Beverage Guidelines stir controversy; Java in JAMA

Filed under: caffeine, Coffee, diet, health, JAMA — medblog @ 6:41 am

A new set of beverage guidelines published in the American Journal of Clinincal Nutririon are causing quite a stir lately. The reccomendations encourage Americans to drink more water or tea and cut back significantly on sweetened sodas. An interesting detail is that the suggestions allow for more beer than lowfat milk on a daily basis. The prominent nutritionists that published the guidelines claim the study was not influenced by funding from the Lipton corporation.

While the above study cites data supporting the safety and possible benefits of caffeine consumption, an article in JAMA addresses the risk of MI from coffee intake. The study by Cornelis et al. links the risk of MI to those that are "slow" caffeine metabolizers. In the study, carriers of a specific CYP1A2 genotype that resulted in slower caffeine metabolism had an increased odds ratio of having an MI if they drank more than 2 cups of coffee per day.

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