Consider The Evidence: Med/Peds Journal Roundup

February 25, 2006

Crohn’s breakthrough: Have we had it wrong all along?

Filed under: crohns, IBD, immunity, lancet — medblog @ 2:43 pm

Lancet 2/25 – In what is being touted as a landmark study, Marks, et al. show evidence that Crohn’s disease is due to an immune deficiency rather than an autoimmune process. This controversial finding seems to contradict the evidence supporting the use of immunosuppressive therapy that has been the mainstay of treatment for years.

The study involved the biopsy of rectal mucosa from Crohn’s pts, UC pts, and healthy controls. Samples were taken from clinically unaffected tissue. Immune cell and cytokine markers were compared among the pre- and post- biopsy samples. The response was significantly lower in the Crohn’s group.

One of the most telling parts of the study involved (more…)

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