Consider The Evidence: Med/Peds Journal Roundup

February 15, 2006

will RIO make you less grande?

Filed under: CVD, JAMA, medicine, obesity — medblog @ 12:16 am

JAMA 2/15 – Do we finally have a drug to help combat obesity? Eagerly awaited results of the RIO trial are published in this weeks JAMA. Rimonabant (trade name: Accomplia) is a novel approach to reducing obesity and other CVD risk factors by targeting endocannabinoid receptors. This is the product of a hotbed of research targeting the signaling pathways that facilitate appetite and weight gain. RIO is the first large scale study of the safety and effectiveness of the drug, and it followed patients over 2 years. The results? Well I guess every little bit helps, but – keep looking for that magic pill.

Not to understate the success…Rimonabant definetly seems to help shed about 10lbs or so and there are significant positive effects on cholesterol levels and insulin sensitivity. (more…)


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