Consider The Evidence: Med/Peds Journal Roundup

August 3, 2006

Actually useful research on dieting?

Filed under: archives of internal medicine, diet, obesity — medblog @ 12:46 pm

ArchIM 6/24 – It is rare enough to see an RCT involving diets, but rarer still to see one with useful results. A study by McMillan-Price in last week’s Archives addressed the issue of diet content. Favor has recently fallen on low glycemic index foods and high protein content. But does this strategy make a difference in weight loss? Yes and No.

The study design divided subjects into 4 groups. Two were high in protein, and two high in carbohydrates. Each pair consisted of a high and low glycemic index group. The overall weight lost was similar in all groups. Bummer, this is starting to look like every other diet trial…

However, LDL levels declined the most in the high-carb, low-glycemic index group, and increased in the high protein, high – GI group. BUT the women in that group (high-protein, high GI) had the greatest number of subjects that lost more than 5% of body weight.

So maybe for women there is something to the Atkins idea as far as weight loss, but this is offset by an increase in cardivascular risk factors(LDL).


February 15, 2006

will RIO make you less grande?

Filed under: CVD, JAMA, medicine, obesity — medblog @ 12:16 am

JAMA 2/15 – Do we finally have a drug to help combat obesity? Eagerly awaited results of the RIO trial are published in this weeks JAMA. Rimonabant (trade name: Accomplia) is a novel approach to reducing obesity and other CVD risk factors by targeting endocannabinoid receptors. This is the product of a hotbed of research targeting the signaling pathways that facilitate appetite and weight gain. RIO is the first large scale study of the safety and effectiveness of the drug, and it followed patients over 2 years. The results? Well I guess every little bit helps, but – keep looking for that magic pill.

Not to understate the success…Rimonabant definetly seems to help shed about 10lbs or so and there are significant positive effects on cholesterol levels and insulin sensitivity. (more…)

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